I was thinking of the time, back in my D&D playing days, when our party was exploring an abandoned fort and some of them found some high zoot booze and proceeded to get shit-waller-wasted.
The party cleric was like, “oh, I think the fuck not,” and whipped up a detox potion he slipped into the next round, sending the revelers crashing precipitously back to sobriety. One of the warriors, who had the lowest Wis. score legally allowed, decided to try the detox potion on an empty stomach, on the theory that it would “un-detox” a sober person and send them back to a state of comprehensive up-fuckédness.
What it did, after a HEFTY con check, was rocket him into a state of heightened sobriety wherein he was acutely, exquisitely attuned to reality and his place in it, the realness of his physical being, and his connection to everything and everyone around him. He was penalized by continual perception checks wherein he’d be advised that he was aware of his underwear. That breathing was AMAZING, and that he could feel his skin cells replacing themselves.
It could have been an aggravating time waster, except it was HILARIOUS seeing it play out and watching the player himself regret the life choices that led him to a character with a natural 3 wisdom score.